MMAB

Across TCGA patient cohorts, MMAB mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MMAB-associated genes across cancer lineages are eIF4E, MEK1, and MSH2. Each is linked with MMAB in more than 1 cancer types. Because this analysis shows association rather than direction, both MMAB-to-partner and partner-to-MMAB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by MMAB-low versus MMAB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMAB→partner) and Y-score (partner→MMAB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.232	+2.584	.018	.011	3	1
UCEC	MEK1 →	+0.381	+2.321	.025	.034	3	1
UCEC	MSH2 →	-0.303	-2.990	.004	.036	3	1
UCEC	Annexin-1 →	+0.492	+2.827	.045	.035	3	1
UCEC	VEGFR2 →	+0.314	+1.887	.023	.031	3	1
UCEC	Chk2_pT68 →	-0.195	-3.312	.024	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

eIF4E by MMAB expression — UCEC

Explore this box plot interactively →