MMAA

Across TCGA patient cohorts, MMAA mutation is significantly associated with the immune_cell of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MMAA-associated genes across cancer lineages are Neutrophils, Platelets, and DC. Each is linked with MMAA in more than 1 cancer types. Because this analysis shows association rather than direction, both MMAA-to-partner and partner-to-MMAA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Neutrophils grouped by MMAA-low versus MMAA-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MMAA→partner) and Y-score (partner→MMAA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	Neutrophils →	+0.009	+3.197	.001	.048	3	1
CESC	Platelets →	+0.017	+4.705	.011	.003	3	1
SKCM	DC →	-0.022	-3.094	.042	.019	3	1
UCEC	aDC →	+0.079	+2.708	.006	.003	3	1
UCEC	CD8+ T-cells →	+0.018	+2.260	<.001	.006	3	1
UCEC	CD8+ Tcm →	+0.035	+2.713	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Neutrophils by MMAA expression — LUAD

Explore this box plot interactively →