MLXIP

Across TCGA pan-cancer cohorts, MLXIP mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of MLXIP’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where MLXIP mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types MLXIP is over-expressed in tumor, although a few such as COAD and LSCC show the opposite, repressed pattern.

COAD, LUAD, and LSCC are the cancer types where MLXIP tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MLXIP mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	−0.696	.001	7	view →
LUAD	All	II,III,IV	+0.203	<.001	7	view →
LSCC	All	All	−0.103	.001	7	view →
CCRCC	Female	III,IV	+0.232	.016	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

MLXIP–COAD

Open the COAD breakdown →