MLX

Across TCGA patient cohorts, MLX protein abundance is significantly associated with the RNA expression of many other genes, with 7,874 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible MLX-associated genes across cancer lineages are MLXIP, MCC, and STX2. Each is linked with MLX in more than 4 cancer types. Because this analysis shows association rather than direction, both MLX-to-partner and partner-to-MLX results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MLX versus MLXIP in UCEC, with a Pearson correlation of 0.46.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLX→partner) and Y-score (partner→MLX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MLXIP →	+0.781	+0.447	<.001	<.001	3	5
LSCC	MCC →	-0.865	-0.343	<.001	<.001	3	3
OV	STX2 →	+1.045	+0.665	<.001	<.001	3	3
OV	ATPAF1 →	-0.608	-0.573	.001	<.001	3	3
OV	SNAI1 →	+0.764	+0.325	.002	.004	3	3
OV	RGS16 →	+0.869	+0.333	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,874 associations by consensus.

MLX vs MLXIP — UCEC

Explore this scatter interactively →