MLX

Across TCGA patient cohorts, MLX mutation is significantly associated with the RNA expression of many other genes, with 184 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MLX-associated genes across cancer lineages are RPL23AP4, PKN3, and MIR3121. Each is linked with MLX in more than 1 cancer types. Because this analysis shows association rather than direction, both MLX-to-partner and partner-to-MLX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL23AP4 grouped by MLX-low versus MLX-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLX→partner) and Y-score (partner→MLX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RPL23AP4 →	+0.121	+3.345	<.001	.001	3	2
UCEC	PKN3 →	+0.832	+2.595	<.001	.006	3	2
UCEC	MIR3121 →	+0.356	+4.260	<.001	<.001	3	2
COAD	MTND5P27 →	+0.210	+6.917	<.001	<.001	3	2
COAD	RN7SL607P →	+0.541	+5.212	<.001	.007	3	2
SKCM	OR52A1 →	+0.038	+5.771	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 184 associations by consensus.

RPL23AP4 by MLX expression — CESC

Explore this box plot interactively →