MLX

Across TCGA patient cohorts, MLX mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MLX-associated genes across cancer lineages are EGFR_pY1068, mTOR_pS2448, and Notch1. Each is linked with MLX in more than 1 cancer types. Because this analysis shows association rather than direction, both MLX-to-partner and partner-to-MLX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by MLX-low versus MLX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLX→partner) and Y-score (partner→MLX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.291	-3.169	.012	.019	3	1
UCEC	mTOR_pS2448 →	-0.164	-3.156	.018	.018	3	1
UCEC	Notch1 →	+0.243	+2.183	<.001	.033	3	1
UCEC	p62 Lck ligand →	+0.479	+2.331	.001	.019	3	1
UCEC	Shc_pY317 →	-0.184	-2.584	.009	.011	3	1
UCEC	Stathmin →	+0.180	+3.026	.004	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

EGFR_pY1068 by MLX expression — UCEC

Explore this box plot interactively →