MLX

Across TCGA cell cohorts, MLX RNA expression is significantly associated with the go_rna of many other GO terms, with 3,145 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MLX-associated GO terms across cancer lineages are DNA strand elongation involved in DNA replication, Centriole replication, and Subtelomeric heterochromatin formation. Each is linked with MLX in more than 9 cancer types. Because this analysis shows association rather than direction, both MLX-to-partner and partner-to-MLX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA strand elongation involved in DNA replication grouped by MLX-low versus MLX-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MLX→partner) and Y-score (partner→MLX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	DNA strand elongation involved in DNA replication →	+0.164	+0.469	<.001	.003	3	9
UPPER_AERODIGESTIVE_TRACT	Centriole replication →	+0.109	+0.829	<.001	<.001	3	9
BREAST	Subtelomeric heterochromatin formation →	+0.115	+0.757	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Traversing start control point of mitotic cell cycle →	+0.140	+0.663	<.001	.001	2	10
UPPER_AERODIGESTIVE_TRACT	Epigenetic regulation of gene expression →	+0.061	+0.873	<.001	<.001	3	9
LUNG_NSCLC_LUSC	External encapsulating structure organization →	-0.149	-0.569	.002	.009	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,145 associations by consensus.

DNA strand elongation involved in DNA replication by MLX expression — SOFT_TISSUE

Explore this box plot interactively →