MLX

Across TCGA cell cohorts, MLX mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MLX-associated genes across cancer lineages are CPLX4, INSL5, and OFCC1. Each is linked with MLX in more than 1 cancer types. Because this analysis shows association rather than direction, both MLX-to-partner and partner-to-MLX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CPLX4 grouped by MLX-low versus MLX-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLX→partner) and Y-score (partner→MLX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CPLX4 →	+0.025	+3.766	.001	.004	3	1
LARGE_INTESTINE	INSL5 →	+0.302	+3.626	<.001	.006	3	1
LARGE_INTESTINE	OFCC1 →	+0.347	+3.556	.006	.007	3	1
LARGE_INTESTINE	SPEM3 →	+0.013	+3.347	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

CPLX4 by MLX expression — LARGE_INTESTINE

Explore this box plot interactively →