MLST8

Across TCGA patient cohorts, MLST8 mutation is significantly associated with the RNA expression of many other genes, with 582 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MLST8-associated genes across cancer lineages are GJE1, RNU6-492P, and MEMO1P3. Each is linked with MLST8 in more than 2 cancer types. Because this analysis shows association rather than direction, both MLST8-to-partner and partner-to-MLST8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GJE1 grouped by MLST8-low versus MLST8-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLST8→partner) and Y-score (partner→MLST8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	GJE1 →	+0.025	+4.302	<.001	.007	3	3
HNSC	RNU6-492P →	+0.478	+7.954	<.001	.008	3	2
CESC	MEMO1P3 →	+0.144	+5.201	<.001	.007	3	2
CESC	SYPL1P1 →	+0.055	+5.539	.002	.004	3	2
UCEC	MTATP6P21 →	+0.325	+2.230	<.001	.005	3	2
UCEC	TCERG1L-AS1 →	+0.223	+1.911	.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 582 associations by consensus.

GJE1 by MLST8 expression — SKCM

Explore this box plot interactively →