MLST8

Across TCGA patient cohorts, MLST8 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MLST8-associated genes across cancer lineages are eIF4E, p62 Lck ligand, and YB-1. Each is linked with MLST8 in more than 1 cancer types. Because this analysis shows association rather than direction, both MLST8-to-partner and partner-to-MLST8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by MLST8-low versus MLST8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLST8→partner) and Y-score (partner→MLST8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.227	+3.321	.020	.010	2	2
UCEC	p62 Lck ligand →	+0.536	+2.469	<.001	.010	3	1
UCEC	YB-1 →	-0.147	-2.558	.047	.011	3	1
UCEC	CD49b →	-0.288	-2.986	.029	.035	3	1
UCEC	MEK1 →	+0.541	+3.700	.001	.001	1	2

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

eIF4E by MLST8 expression — UCEC

Explore this box plot interactively →