MLST8

Across TCGA cell cohorts, MLST8 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MLST8-associated genes across cancer lineages are CCL25, NUPR2, and ADAM7. Each is linked with MLST8 in more than 1 cancer types. Because this analysis shows association rather than direction, both MLST8-to-partner and partner-to-MLST8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCL25 grouped by MLST8-low versus MLST8-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLST8→partner) and Y-score (partner→MLST8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CCL25 →	+0.060	+4.095	.001	.009	3	1
LARGE_INTESTINE	NUPR2 →	+0.376	+4.273	<.001	.006	3	1
LARGE_INTESTINE	ADAM7 →	+0.007	+4.930	<.001	.001	3	1
LARGE_INTESTINE	F11 →	+0.057	+4.467	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

CCL25 by MLST8 expression — SKIN

Explore this box plot interactively →