MLPH

Across TCGA pan-cancer cohorts, MLPH mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MLPH data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher MLPH mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MLPH expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

CCRCC, PDAC, and LSCC are the cancer types where MLPH mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	III,IV	0.235	0.879	<.001	53	view →
PDAC	OS	Median	All	0.714	0.446	.006	32	view →
LSCC	DFS	Median	All	0.894	0.976	.006	13	view →
UCEC	DFS	Tertile	All	0.974	0.860	.020	8	view →
LUAD	DFS	Quartile	All	0.801	1.000	.003	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MLPH–CCRCC (DFS)

Open the CCRCC breakdown →