MLPH

Across TCGA patient cohorts, MLPH protein abundance is significantly associated with the RNA expression of many other genes, with 18,849 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible MLPH-associated genes across cancer lineages are AGR2, TSPAN1, and SPDEF. Each is linked with MLPH in more than 6 cancer types. Because this analysis shows association rather than direction, both MLPH-to-partner and partner-to-MLPH results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MLPH versus AGR2 in BRCA, with a Pearson correlation of 0.78.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLPH→partner) and Y-score (partner→MLPH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	AGR2 →	+4.167	+0.983	<.001	<.001	3	7
BRCA	TSPAN1 →	+1.934	+0.881	<.001	<.001	3	7
BRCA	SPDEF →	+2.734	+0.990	<.001	<.001	3	7
BRCA	TFF3 →	+3.946	+1.051	<.001	<.001	3	7
BRCA	TFF1 →	+4.601	+1.039	<.001	<.001	3	7
BRCA	AGR3 →	+4.266	+1.106	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,849 associations by consensus.

MLPH vs AGR2 — BRCA

Explore this scatter interactively →