MLPH

Across TCGA patient cohorts, MLPH mutation is significantly associated with the RNA expression of many other genes, with 3,095 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MLPH-associated genes across cancer lineages are MIR1228, MIR6859-2, and RNA5SP176. Each is linked with MLPH in more than 3 cancer types. Because this analysis shows association rather than direction, both MLPH-to-partner and partner-to-MLPH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR1228 grouped by MLPH-low versus MLPH-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLPH→partner) and Y-score (partner→MLPH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR1228 →	+0.158	+4.810	<.001	.002	3	4
BRCA	MIR6859-2 →	+0.585	+4.108	.005	.002	3	3
BLCA	RNA5SP176 →	+0.338	+7.640	<.001	.009	3	3
BRCA	RNU6-273P →	+0.222	+4.442	<.001	.006	3	2
BLCA	RNA5SP454 →	+0.298	+7.640	<.001	.009	3	2
BLCA	ELOCP5 →	+0.239	+7.640	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,095 associations by consensus.

MIR1228 by MLPH expression — SKCM

Explore this box plot interactively →