MLPH

Across TCGA cell cohorts, MLPH RNA expression is significantly associated with the go_rna of many other GO terms, with 5,255 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible MLPH-associated GO terms across cancer lineages are Regulation of tolerance induction dependent upon immune response, Regulation of angiotensin-activated signaling pathway, and Positive regulation of transmembrane transport. Each is linked with MLPH in more than 10 cancer types. Because this analysis shows association rather than direction, both MLPH-to-partner and partner-to-MLPH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of tolerance induction dependent upon immune response grouped by MLPH-low versus MLPH-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MLPH→partner) and Y-score (partner→MLPH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of tolerance induction dependent upon immune response →	+1.638	+5.212	<.001	<.001	3	11
BONE	Regulation of angiotensin-activated signaling pathway →	+0.195	+1.453	<.001	.001	3	10
STOMACH	Positive regulation of transmembrane transport →	+0.069	+3.637	.008	<.001	3	10
LUNG_NSCLC_LUSC	Heme transport →	-0.185	-3.791	<.001	<.001	3	10
SOFT_TISSUE	Regulation of body fluid levels →	+0.102	+3.234	<.001	<.001	3	10
URINARY_TRACT	Negative regulation of cardiac muscle adaptation →	+0.286	+3.159	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,255 associations by consensus.

Regulation of tolerance induction dependent upon immune response by MLPH expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →