MLPH

Across TCGA cell cohorts, MLPH mutation is significantly associated with the mutation status of many other genes, with 3,112 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MLPH-associated genes across cancer lineages are CWF19L2, SYNJ1, and PTCRA. Each is linked with MLPH in more than 2 cancer types. Because this analysis shows association rather than direction, both MLPH-to-partner and partner-to-MLPH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CWF19L2 grouped by MLPH-low versus MLPH-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLPH→partner) and Y-score (partner→MLPH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CWF19L2 →	+4.824	+5.392	.004	.004	1	3
LUNG_NSCLC_LUAD	SYNJ1 →	+5.339	+4.772	.004	.004	1	3
SKIN	PTCRA →	+5.824	+5.824	.002	.002	1	3
LUNG_NSCLC_LUAD	PLTP →	+4.339	+4.339	.009	.009	1	3
BLOOD_Leukemia	NALCN →	+2.823	+3.665	.008	.008	1	3
BLOOD_Leukemia	TBC1D9 →	+3.338	+4.083	.003	.003	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,112 associations by consensus.

CWF19L2 by MLPH expression — SKIN

Explore this box plot interactively →