MLNR

Across TCGA cell cohorts, MLNR mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MLNR-associated genes across cancer lineages are C1QBP, MMP26, and BMP15. Each is linked with MLNR in more than 1 cancer types. Because this analysis shows association rather than direction, both MLNR-to-partner and partner-to-MLNR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1QBP grouped by MLNR-low versus MLNR-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLNR→partner) and Y-score (partner→MLNR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C1QBP →	+0.813	+3.131	.001	.008	3	1
LARGE_INTESTINE	MMP26 →	+0.027	+3.310	<.001	<.001	3	1
BLOOD_Lymphoma	BMP15 →	+0.029	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	TLX3 →	+0.016	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	NLRP8 →	+0.041	+4.867	<.001	.009	3	1
LARGE_INTESTINE	HSPD1 →	+0.611	+3.125	.003	.008	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

C1QBP by MLNR expression — LARGE_INTESTINE

Explore this box plot interactively →