MLLT6

Across TCGA patient cohorts, MLLT6 mutation is significantly associated with the RNA expression of many other genes, with 4,823 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MLLT6-associated genes across cancer lineages are FANCG, PTMAP4, and MAPK7. Each is linked with MLLT6 in more than 2 cancer types. Because this analysis shows association rather than direction, both MLLT6-to-partner and partner-to-MLLT6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FANCG grouped by MLLT6-low versus MLLT6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLLT6→partner) and Y-score (partner→MLLT6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FANCG →	+0.375	+1.934	.004	.002	3	3
COAD	PTMAP4 →	+1.661	+2.727	<.001	.003	3	3
UCEC	MAPK7 →	+0.414	+2.550	<.001	<.001	3	3
UCEC	PGAM1 →	+0.842	+2.223	<.001	<.001	3	3
UCEC	CCNK →	+0.454	+2.425	<.001	.001	3	3
COAD	NARS1 →	+0.497	+3.490	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,823 associations by consensus.

FANCG by MLLT6 expression — UCEC

Explore this box plot interactively →