MLLT6

Across TCGA patient cohorts, MLLT6 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MLLT6-associated genes across cancer lineages are GATA6, MEK1, and MSH2. Each is linked with MLLT6 in more than 1 cancer types. Because this analysis shows association rather than direction, both MLLT6-to-partner and partner-to-MLLT6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GATA6 grouped by MLLT6-low versus MLLT6-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLLT6→partner) and Y-score (partner→MLLT6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GATA6 →	-0.279	-3.459	.001	.005	3	2
UCEC	MEK1 →	+0.469	+4.321	<.001	<.001	3	2
UCEC	MSH2 →	-0.250	-1.674	.001	.040	3	2
UCEC	MSH6 →	-0.324	-1.700	.003	.040	3	2
COAD	PCNA →	+0.359	+3.467	.001	.002	3	2
UCEC	Rad50 →	-0.291	-1.874	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

GATA6 by MLLT6 expression — COAD

Explore this box plot interactively →