MLLT6

Across TCGA cell cohorts, MLLT6 mutation is significantly associated with the RNA expression of many other genes, with 610 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MLLT6-associated genes across cancer lineages are LPA, GAGE12E, and METRN. Each is linked with MLLT6 in more than 1 cancer types. Because this analysis shows association rather than direction, both MLLT6-to-partner and partner-to-MLLT6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LPA grouped by MLLT6-low versus MLLT6-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLLT6→partner) and Y-score (partner→MLLT6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	LPA →	+0.784	+3.717	<.001	.005	3	2
BLOOD_Lymphoma	GAGE12E →	+0.676	+3.459	<.001	.004	3	2
BLOOD_Leukemia	METRN →	+1.171	+3.199	.004	.007	3	2
BLOOD_Leukemia	RIC8B →	+0.717	+3.199	.005	.007	3	2
BLOOD_Leukemia	TRIM62 →	+0.669	+3.199	.003	.007	3	2
BLOOD_Leukemia	RPA1 →	+0.672	+3.199	.005	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 610 associations by consensus.

LPA by MLLT6 expression — BLOOD_Lymphoma

Explore this box plot interactively →