MLLT3

Across TCGA pan-cancer cohorts, MLLT3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated MLLT3 data layer compared with 19 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher MLLT3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MLLT3 expression acts as an unfavorable survival marker, although some lineages such as LSCC and UCEC show a favorable association.

LSCC, UCEC, and PDAC are the cancer types where MLLT3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	All	0.930	0.510	<.001	29	view →
UCEC	DFS	Tertile	All	0.967	0.878	.035	6	view →
PDAC	OS	Median	III,IV	0.241	1.000	.038	6	view →
CCRCC	OS	Quartile	III,IV	0.908	0.394	.035	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

MLLT3–LSCC (DFS)

Open the LSCC breakdown →