MLLT3

Across TCGA cell cohorts, MLLT3 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible MLLT3-associated genes across cancer lineages are OR10R2, GOLGA6L1, and DNAAF6. Each is linked with MLLT3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MLLT3-to-partner and partner-to-MLLT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10R2 grouped by MLLT3-low versus MLLT3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLLT3→partner) and Y-score (partner→MLLT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR10R2 →	+1.144	+3.551	.007	.009	3	1
BLOOD_Leukemia	GOLGA6L1 →	+0.042	+4.060	<.001	.003	3	1
BLOOD_Leukemia	DNAAF6 →	+0.031	+3.847	.001	.007	3	1
LARGE_INTESTINE	TP53TG3E →	+0.019	+5.345	<.001	<.001	3	1
CNS	F9 →	+0.032	+4.321	<.001	.009	3	1
CNS	ATXN3L →	+0.028	+4.315	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

OR10R2 by MLLT3 expression — BLOOD_Leukemia

Explore this box plot interactively →