Across TCGA patient cohorts, MLLT11 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MLLT11-associated genes across cancer lineages are ACC_pS79, Annexin-1, and Caspase-7-cleavedD198. Each is linked with MLLT11 in more than 1 cancer types. Because this analysis shows association rather than direction, both MLLT11-to-partner and partner-to-MLLT11 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLLT11→partner) and Y-score (partner→MLLT11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC_pS79 →	+0.560	+2.817	.005	.036	3	1
UCEC	Annexin-1 →	+0.733	+3.000	.016	.037	3	1
UCEC	Caspase-7-cleavedD198 →	+1.057	+2.827	.002	.035	3	1
UCEC	C-Raf →	+0.302	+3.000	<.001	.036	3	1
UCEC	EGFR_pY1068 →	-0.320	-3.000	.027	.037	2	1
UCEC	p70-S6K_pT389 →	-0.259	-3.000	.018	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

MLLT11 survival (RNA) · tumor vs normal (RNA) · all MLLT11 data types