MLLT10

Across TCGA cell cohorts, MLLT10 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MLLT10-associated genes across cancer lineages are KLK15, SERPINA7, and C1orf158. Each is linked with MLLT10 in more than 1 cancer types. Because this analysis shows association rather than direction, both MLLT10-to-partner and partner-to-MLLT10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLK15 grouped by MLLT10-low versus MLLT10-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLLT10→partner) and Y-score (partner→MLLT10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	KLK15 →	+0.055	+3.980	.001	.002	3	2
BLOOD_Myeloma	SERPINA7 →	+0.459	+4.807	<.001	.006	3	1
BLOOD_Myeloma	C1orf158 →	+0.053	+4.807	<.001	.006	3	1
BLOOD_Lymphoma	OR52B2 →	+0.021	+4.714	.006	.002	3	1
UPPER_AERODIGESTIVE_TRACT	FAM236A →	+0.090	+4.357	<.001	.006	3	1
UPPER_AERODIGESTIVE_TRACT	PPIAL4F →	+0.117	+4.510	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

KLK15 by MLLT10 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →