MLIP

Across TCGA patient cohorts, MLIP mutation is significantly associated with the RNA expression of many other genes, with 3,209 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MLIP-associated genes across cancer lineages are SURF2, DCPS, and HIRIP3. Each is linked with MLIP in more than 2 cancer types. Because this analysis shows association rather than direction, both MLIP-to-partner and partner-to-MLIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SURF2 grouped by MLIP-low versus MLIP-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLIP→partner) and Y-score (partner→MLIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SURF2 →	+0.375	+2.143	.001	<.001	3	3
UCEC	DCPS →	+0.304	+1.379	.007	.002	3	3
UCEC	HIRIP3 →	+0.420	+2.833	<.001	<.001	3	3
BRCA	MYO5BP1 →	+0.091	+4.209	<.001	.009	3	2
SKCM	HMGN2P17 →	+0.487	+2.434	<.001	.001	3	2
SKCM	RPL26P3 →	+0.044	+1.828	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,209 associations by consensus.

SURF2 by MLIP expression — SKCM

Explore this box plot interactively →