MLH3

Across TCGA patient cohorts, MLH3 RNA expression is significantly associated with the protein abundance of many other proteins, with 18,180 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible MLH3-associated proteins across cancer lineages are ZC3H14, UBR7, and YLPM1. Each is linked with MLH3 in more than 7 cancer types. Because this analysis shows association rather than direction, both MLH3-to-partner and partner-to-MLH3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MLH3 versus ZC3H14 in GBM, with a Pearson correlation of 0.35.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MLH3→partner) and Y-score (partner→MLH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ZC3H14 →	+0.196	+0.334	.001	<.001	3	8
BRCA	UBR7 →	+0.335	+0.433	<.001	<.001	3	8
GBM	YLPM1 →	+0.311	+0.455	<.001	<.001	3	7
LSCC	ACIN1 →	+0.205	+0.442	<.001	.001	3	7
LSCC	BRF1 →	+0.321	+0.467	.001	<.001	3	7
BRCA	DNTTIP1 →	+0.320	+0.596	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,180 associations by consensus.

MLH3 vs ZC3H14 — GBM

Explore this scatter interactively →