MLH3

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, MLH3 protein abundance is significantly associated with the RNA expression of many other genes, with 1,583 significant associations in total. GBM shows the largest number of these associations.

The most reproducible MLH3-associated genes across cancer lineages are MIR181A2HG, TMBIM1, and MIR107. Each is linked with MLH3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MLH3-to-partner and partner-to-MLH3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MLH3 versus MIR181A2HG in LUAD, with a Pearson correlation of 0.55.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLH3→partner) and Y-score (partner→MLH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUADMIR181A2HG →+0.956+0.545<.001<.00132
LSCCTMBIM1 →-0.772-0.420<.001<.00132
LUADMIR107 →+1.079+0.378.009.00932
GBMCARD16 →-1.005-0.221.004.00632
GBMRIN1 →-0.996-0.277.001<.00132
GBMCYCSP1 →+0.828+0.294.002.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 1,583 associations by consensus.

MLH3 vs MIR181A2HG — LUAD

Per-sample scatter of MLH3 vs MIR181A2HG in LUAD (Pearson r = 0.55).

Explore this scatter interactively →

Exploration