MLH3

Across TCGA patient cohorts, MLH3 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MLH3-associated genes across cancer lineages are ERK2, Caspase-7-cleavedD198, and MEK1. Each is linked with MLH3 in more than 2 cancer types. Because this analysis shows association rather than direction, both MLH3-to-partner and partner-to-MLH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by MLH3-low versus MLH3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLH3→partner) and Y-score (partner→MLH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.119	+1.584	.038	.032	3	3
UCEC	Caspase-7-cleavedD198 →	+0.604	+1.671	<.001	.003	3	3
UCEC	MEK1 →	+0.412	+2.050	<.001	<.001	3	2
COAD	TSC1 →	-0.269	-3.161	.048	.019	3	2
COAD	Di-Ras3 →	-0.280	-3.161	.003	.019	3	2
UCEC	14-3-3_beta →	-0.086	-1.651	.004	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

ERK2 by MLH3 expression — UCEC

Explore this box plot interactively →