MLH3

Across TCGA cell cohorts, MLH3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,653 significant associations in total. BONE shows the largest number of these associations.

The most reproducible MLH3-associated GO terms across cancer lineages are Positive regulation of lymphoid progenitor cell differentiation, Regulation of alternative mRNA splicing, via spliceosome, and Protein catabolic process at synapse. Each is linked with MLH3 in more than 10 cancer types. Because this analysis shows association rather than direction, both MLH3-to-partner and partner-to-MLH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of lymphoid progenitor cell differentiation grouped by MLH3-low versus MLH3-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MLH3→partner) and Y-score (partner→MLH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Positive regulation of lymphoid progenitor cell differentiation →	+0.138	+0.976	.001	.004	3	11
OESOPHAGUS	Regulation of alternative mRNA splicing, via spliceosome →	+0.106	+1.049	<.001	.001	3	10
LIVER	Protein catabolic process at synapse →	+0.129	+0.645	.002	<.001	3	10
LIVER	Protein catabolic process at postsynapse →	+0.129	+0.645	.002	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Cilium-dependent cell motility →	-0.115	-1.025	<.001	.001	3	10
UPPER_AERODIGESTIVE_TRACT	Cilium movement involved in cell motility →	-0.092	-0.890	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,653 associations by consensus.

Positive regulation of lymphoid progenitor cell differentiation by MLH3 expression — STOMACH

Explore this box plot interactively →