MLH3

Across TCGA cell cohorts, MLH3 mutation is significantly associated with the RNA expression of many other genes, with 379 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MLH3-associated genes across cancer lineages are TBC1D3K, OR2V2, and PSAT1. Each is linked with MLH3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MLH3-to-partner and partner-to-MLH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBC1D3K grouped by MLH3-low versus MLH3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLH3→partner) and Y-score (partner→MLH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TBC1D3K →	+0.149	+2.969	<.001	.007	3	2
LUNG_NSCLC_LUAD	OR2V2 →	+0.022	+3.959	<.001	.001	3	2
LARGE_INTESTINE	PSAT1 →	+1.058	+2.502	.002	.005	3	2
LARGE_INTESTINE	GDAP2 →	+0.643	+2.502	<.001	.005	3	2
LARGE_INTESTINE	MRPL42 →	+0.557	+2.502	.002	.005	3	2
LARGE_INTESTINE	DNAJA2 →	+0.419	+3.067	.005	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 379 associations by consensus.

TBC1D3K by MLH3 expression — SKIN

Explore this box plot interactively →