MLH1

Across TCGA pan-cancer cohorts, MLH1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MLH1 data layer compared with 23 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher MLH1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated MLH1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

LUAD, PDAC, and HNSC are the cancer types where MLH1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.808	0.299	.026	12	view →
PDAC	OS	Tertile	II,III,IV	0.638	1.000	<.001	6	view →
HNSC	DFS	Tertile	IV	0.700	0.929	.043	2	view →
LSCC	OS	Tertile	All	0.909	0.738	.023	1	view →
CCRCC	DFS	Median	All	0.822	0.664	.027	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MLH1–LUAD (OS)

Open the LUAD breakdown →