MLH1

Across TCGA patient cohorts, MLH1 protein abundance is significantly associated with the RNA expression of many other genes, with 13,023 significant associations in total. GBM shows the largest number of these associations.

The most reproducible MLH1-associated genes across cancer lineages are EIF3B, RPA3, and POLD2. Each is linked with MLH1 in more than 5 cancer types. Because this analysis shows association rather than direction, both MLH1-to-partner and partner-to-MLH1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MLH1 versus EIF3B in HNSC, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLH1→partner) and Y-score (partner→MLH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	EIF3B →	+0.628	+0.234	.001	<.001	3	6
HNSC	RPA3 →	+0.758	+0.250	<.001	<.001	3	6
LSCC	POLD2 →	+0.554	+0.205	<.001	<.001	3	6
LUAD	PMS2 →	+0.487	+0.190	<.001	<.001	3	6
GBM	KIF2C →	+0.896	+0.252	<.001	<.001	3	6
HNSC	CENPH →	+0.812	+0.235	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,023 associations by consensus.

MLH1 vs EIF3B — HNSC

Explore this scatter interactively →