MLH1

Across TCGA patient cohorts, MLH1 mutation is significantly associated with the RNA expression of many other genes, with 1,823 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MLH1-associated genes across cancer lineages are PSMD9, MIR4790, and RN7SL447P. Each is linked with MLH1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MLH1-to-partner and partner-to-MLH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMD9 grouped by MLH1-low versus MLH1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLH1→partner) and Y-score (partner→MLH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PSMD9 →	+0.335	+1.954	.001	<.001	3	3
LUAD	MIR4790 →	+0.611	+6.924	<.001	<.001	3	3
UCEC	RN7SL447P →	+0.144	+1.888	<.001	.001	3	3
BRCA	HMGN1P31 →	+0.186	+4.639	<.001	.005	3	2
CESC	MIR1224 →	+0.298	+4.020	<.001	.009	3	2
CESC	RPEP3 →	+0.103	+4.270	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,823 associations by consensus.

PSMD9 by MLH1 expression — UCEC

Explore this box plot interactively →