MLH1

Across TCGA cell cohorts, MLH1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,149 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MLH1-associated GO terms across cancer lineages are Positive regulation of cell cycle process, Positive regulation of mitotic cell cycle phase transition, and Regulation of chromosome segregation. Each is linked with MLH1 in more than 14 cancer types. Because this analysis shows association rather than direction, both MLH1-to-partner and partner-to-MLH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of cell cycle process grouped by MLH1-low versus MLH1-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MLH1→partner) and Y-score (partner→MLH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Positive regulation of cell cycle process →	+0.091	+0.706	.001	<.001	3	15
KIDNEY	Positive regulation of mitotic cell cycle phase transition →	+0.105	+0.759	<.001	.002	3	14
LIVER	Regulation of chromosome segregation →	+0.107	+0.849	.001	.002	3	14
SOFT_TISSUE	Positive regulation of chromosome condensation →	+0.227	+0.815	<.001	.001	3	14
KIDNEY	Positive regulation of cell cycle phase transition →	+0.118	+1.077	<.001	<.001	3	13
LIVER	Regulation of metaphase/anaphase transition of cell cycle →	+0.111	+0.792	.002	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,149 associations by consensus.

Positive regulation of cell cycle process by MLH1 expression — KIDNEY

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