MLH1

Across TCGA cell cohorts, MLH1 mutation is significantly associated with the RNA expression of many other genes, with 1,707 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MLH1-associated genes across cancer lineages are MINPP1, RIC8B, and PPP2R5D. Each is linked with MLH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MLH1-to-partner and partner-to-MLH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MINPP1 grouped by MLH1-low versus MLH1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLH1→partner) and Y-score (partner→MLH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MINPP1 →	+0.669	+2.584	<.001	.002	3	2
LARGE_INTESTINE	RIC8B →	+0.498	+2.850	.001	<.001	3	2
LARGE_INTESTINE	PPP2R5D →	+0.637	+3.649	<.001	<.001	3	2
LARGE_INTESTINE	MTERF2 →	+0.554	+2.649	<.001	.001	3	2
LARGE_INTESTINE	PSMD6 →	+0.379	+2.158	.008	.004	3	2
LARGE_INTESTINE	MANEAL →	+1.010	+3.321	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,707 associations by consensus.

MINPP1 by MLH1 expression — LARGE_INTESTINE

Explore this box plot interactively →