MLF2

Across TCGA pan-cancer cohorts, MLF2 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of MLF2’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where MLF2 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types MLF2 is over-expressed in tumor, although a few such as CCRCC and LUAD show the opposite, repressed pattern.

LSCC, CCRCC, and LUAD are the cancer types where MLF2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MLF2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	All	+0.672	<.001	8	view →
CCRCC	Male	All	−0.139	.001	2	view →
LUAD	Female	III,IV	−0.340	.026	1	view →
COAD	Male	III,IV	−0.289	.004	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

MLF2–LSCC

Open the LSCC breakdown →