MLF2

Across TCGA cell cohorts, MLF2 mutation is significantly associated with the mutation status of many other genes, with 3,076 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MLF2-associated genes across cancer lineages are ZFP37, RIPOR1, and ZNF451. Each is linked with MLF2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MLF2-to-partner and partner-to-MLF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZFP37 grouped by MLF2-low versus MLF2-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLF2→partner) and Y-score (partner→MLF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ZFP37 →	+5.000	+4.437	.007	.007	1	3
SKIN	RIPOR1 →	+4.392	+4.392	.009	.009	1	3
LARGE_INTESTINE	ZNF451 →	+2.000	+4.087	<.001	<.001	1	3
UPPER_AERODIGESTIVE_TRACT	TRPS1 →	+4.392	+4.954	.008	.008	1	3
UPPER_AERODIGESTIVE_TRACT	SRSF4 →	+5.392	+5.392	.004	.004	1	3
UPPER_AERODIGESTIVE_TRACT	KIF21A →	+4.392	+4.954	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,076 associations by consensus.

ZFP37 by MLF2 expression — BONE

Explore this box plot interactively →