MLF1

Across TCGA pan-cancer cohorts, MLF1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated MLF1 data layer compared with 28 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher MLF1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MLF1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

STAD, BLCA, and UCEC are the cancer types where MLF1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Median	II,III,IV	0.074	0.660	<.001	30	view →
BLCA	OS	Median	IV	0.094	0.605	<.001	12	view →
UCEC	DFS	Median	II,III,IV	1.000	0.438	.017	12	view →
COAD	OS	Median	All	0.221	0.799	.022	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

MLF1–STAD (OS)

Open the STAD breakdown →