MLF1

Across TCGA pan-cancer cohorts, MLF1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated MLF1 data layer compared with 28 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher MLF1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MLF1 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

PDAC, CCRCC, and GBM are the cancer types where MLF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.254	0.615	.021	4	view →
CCRCC	OS	Median	III,IV	0.387	0.966	.038	2	view →
GBM	DFS	Quartile	All	0.567	0.227	.017	2	view →
LSCC	DFS	Median	II,III,IV	0.862	0.970	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

MLF1–PDAC (DFS)

Open the PDAC breakdown →