MLEC

Across TCGA patient cohorts, MLEC protein abundance is significantly associated with the RNA expression of many other genes, with 14,355 significant associations in total. GBM shows the largest number of these associations.

The most reproducible MLEC-associated genes across cancer lineages are SMC3, CASP8AP2, and PPIL4. Each is linked with MLEC in more than 3 cancer types. Because this analysis shows association rather than direction, both MLEC-to-partner and partner-to-MLEC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MLEC versus SMC3 in UCEC, with a Pearson correlation of -0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLEC→partner) and Y-score (partner→MLEC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SMC3 →	-0.474	-0.531	.002	.001	3	4
GBM	CASP8AP2 →	-0.666	-0.439	<.001	<.001	3	4
UCEC	PPIL4 →	-0.316	-0.718	.002	<.001	3	4
BRCA	NES →	-1.101	-0.544	<.001	<.001	3	4
COAD	GYPC →	-0.662	-0.324	.002	.001	3	4
UCEC	SPARCL1 →	-1.820	-0.769	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,355 associations by consensus.

MLEC vs SMC3 — UCEC

Explore this scatter interactively →