MLEC

Across TCGA patient cohorts, MLEC mutation is significantly associated with the RNA expression of many other genes, with 952 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MLEC-associated genes across cancer lineages are MTND5P35, RNU1-20P, and PRELID3BP1. Each is linked with MLEC in more than 1 cancer types. Because this analysis shows association rather than direction, both MLEC-to-partner and partner-to-MLEC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTND5P35 grouped by MLEC-low versus MLEC-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLEC→partner) and Y-score (partner→MLEC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MTND5P35 →	+0.028	+5.124	<.001	<.001	3	2
LUAD	RNU1-20P →	+0.430	+4.037	<.001	.004	3	2
LUAD	PRELID3BP1 →	+0.159	+3.855	<.001	.006	3	2
COAD	MIR147A →	+0.451	+4.893	.002	.005	3	2
SKCM	RN7SKP171 →	+0.149	+7.816	<.001	.008	3	2
UCEC	SNORD105 →	+0.538	+1.952	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 952 associations by consensus.

MTND5P35 by MLEC expression — CESC

Explore this box plot interactively →