MLEC

Across TCGA patient cohorts, MLEC mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MLEC-associated genes across cancer lineages are PCNA, 14-3-3_beta, and GAPDH. Each is linked with MLEC in more than 1 cancer types. Because this analysis shows association rather than direction, both MLEC-to-partner and partner-to-MLEC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by MLEC-low versus MLEC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLEC→partner) and Y-score (partner→MLEC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.207	+2.000	.033	.032	3	2
UCEC	14-3-3_beta →	-0.117	-2.973	.010	.035	3	1
UCEC	GAPDH →	+0.548	+3.321	.023	.009	3	1
UCEC	Ku80 →	+0.334	+3.472	.001	.002	3	1
UCEC	p62 Lck ligand →	+0.400	+3.179	.006	.010	3	1
UCEC	S6_pS240_S244 →	+0.467	+3.169	.010	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

PCNA by MLEC expression — UCEC

Explore this box plot interactively →