MLC1

Across TCGA patient cohorts, MLC1 protein abundance is significantly associated with the RNA expression of many other genes, with 2,572 significant associations in total. GBM shows the largest number of these associations.

The most reproducible MLC1-associated genes across cancer lineages are MAPK1, PRODH, and CYTH4. Each is linked with MLC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MLC1-to-partner and partner-to-MLC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MLC1 versus MAPK1 in GBM, with a Pearson correlation of 0.31.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLC1→partner) and Y-score (partner→MLC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MAPK1 →	+0.258	+0.289	.002	.006	3	1
GBM	PRODH →	+1.024	+0.406	<.001	<.001	3	1
GBM	CYTH4 →	-0.585	-0.369	.007	.005	3	1
GBM	SEZ6L →	+1.629	+0.476	<.001	<.001	3	1
GBM	SRRD →	+0.215	+0.280	.002	.008	3	1
GBM	GCAT →	+0.547	+0.380	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,572 associations by consensus.

MLC1 vs MAPK1 — GBM

Explore this scatter interactively →