MLC1

Across TCGA patient cohorts, MLC1 mutation is significantly associated with the RNA expression of many other genes, with 1,007 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MLC1-associated genes across cancer lineages are NF2, OR10AG1, and RNA5SP45. Each is linked with MLC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MLC1-to-partner and partner-to-MLC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NF2 grouped by MLC1-low versus MLC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLC1→partner) and Y-score (partner→MLC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NF2 →	+0.517	+3.364	.001	.004	3	3
HNSC	OR10AG1 →	+0.046	+6.339	.001	.001	3	3
PRAD	RNA5SP45 →	+0.343	+7.939	<.001	.008	3	2
SKCM	RNA5SP24 →	+0.161	+3.594	<.001	.002	3	2
SKCM	A2ML1-AS1 →	+0.088	+2.683	<.001	<.001	3	2
SKCM	LINC02304 →	+0.034	+3.750	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,007 associations by consensus.

NF2 by MLC1 expression — UCEC

Explore this box plot interactively →