MLC1

Across TCGA patient cohorts, MLC1 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MLC1-associated genes across cancer lineages are MSH2, 4E-BP1, and Cyclin-B1. Each is linked with MLC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MLC1-to-partner and partner-to-MLC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by MLC1-low versus MLC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLC1→partner) and Y-score (partner→MLC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.351	-2.973	.002	.035	3	2
UCEC	4E-BP1 →	+0.329	+2.321	.015	.035	3	2
UCEC	Cyclin-B1 →	+0.602	+3.000	.032	.036	3	2
UCEC	EGFR_pY1068 →	-0.249	-2.321	.048	.035	3	1
UCEC	ERK2 →	+0.276	+2.321	.004	.034	3	1
UCEC	INPP4B →	-0.357	-3.446	.028	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

MSH2 by MLC1 expression — UCEC

Explore this box plot interactively →