MLC1

Across TCGA cell cohorts, MLC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,076 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MLC1-associated GO terms across cancer lineages are Purine ribonucleotide biosynthetic process, Purine ribonucleotide metabolic process, and Regulation of translational initiation. Each is linked with MLC1 in more than 6 cancer types. Because this analysis shows association rather than direction, both MLC1-to-partner and partner-to-MLC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Purine ribonucleotide biosynthetic process grouped by MLC1-low versus MLC1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MLC1→partner) and Y-score (partner→MLC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Purine ribonucleotide biosynthetic process →	+0.110	+2.878	<.001	<.001	3	7
OESOPHAGUS	Purine ribonucleotide metabolic process →	+0.053	+0.278	<.001	.009	3	6
CNS	Regulation of translational initiation →	+0.050	+1.321	<.001	.002	3	6
UPPER_AERODIGESTIVE_TRACT	Proton motive force-driven ATP synthesis →	+0.064	+0.151	.008	.001	3	6
UPPER_AERODIGESTIVE_TRACT	ATP metabolic process →	+0.083	+0.150	<.001	<.001	2	7
BONE	Protein-DNA complex assembly →	+0.077	+2.964	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,076 associations by consensus.

Purine ribonucleotide biosynthetic process by MLC1 expression — BONE

Explore this box plot interactively →