MLANA

Across TCGA patient cohorts, MLANA mutation is significantly associated with the RNA expression of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MLANA-associated genes across cancer lineages are RNU6-1292P, PGBD4P2, and RNA5SP106. Each is linked with MLANA in more than 1 cancer types. Because this analysis shows association rather than direction, both MLANA-to-partner and partner-to-MLANA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1292P grouped by MLANA-low versus MLANA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLANA→partner) and Y-score (partner→MLANA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-1292P →	+0.346	+4.132	<.001	.009	3	2
READ	PGBD4P2 →	+0.162	+6.257	<.001	.001	3	1
BRCA	RNA5SP106 →	+0.554	+9.057	<.001	.003	3	1
UCEC	RNA5SP393 →	+0.408	+3.766	.001	.001	3	1
UCEC	MIR188 →	+0.334	+5.167	<.001	<.001	3	1
UCEC	SNRPEP6 →	+0.382	+3.560	.005	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

RNU6-1292P by MLANA expression — UCEC

Explore this box plot interactively →