MLANA

Across TCGA cell cohorts, MLANA RNA expression is significantly associated with the go_rna of many other GO terms, with 3,678 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible MLANA-associated GO terms across cancer lineages are Cytosolic transport, Mitochondrion-endoplasmic reticulum membrane tethering, and Cilium or flagellum-dependent cell motility. Each is linked with MLANA in more than 12 cancer types. Because this analysis shows association rather than direction, both MLANA-to-partner and partner-to-MLANA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cytosolic transport grouped by MLANA-low versus MLANA-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MLANA→partner) and Y-score (partner→MLANA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Cytosolic transport →	+0.089	+0.417	<.001	<.001	3	13
SKIN	Mitochondrion-endoplasmic reticulum membrane tethering →	+0.121	+6.021	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Cilium or flagellum-dependent cell motility →	-0.121	-0.297	<.001	.002	3	9
UPPER_AERODIGESTIVE_TRACT	Cilium-dependent cell motility →	-0.121	-0.297	<.001	.002	3	9
UPPER_AERODIGESTIVE_TRACT	Cilium movement involved in cell motility →	-0.123	-0.284	<.001	.003	3	9
LUNG_NSCLC_LUSC	Positive regulation of mRNA catabolic process →	+0.074	+0.251	<.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,678 associations by consensus.

Cytosolic transport by MLANA expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →