MLANA

Across TCGA cell cohorts, MLANA protein abundance is significantly associated with the RNA expression of many other genes, with 565 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible MLANA-associated genes across cancer lineages are HPS4, RAB36, and SNW1. Each is linked with MLANA in more than 1 cancer types. Because this analysis shows association rather than direction, both MLANA-to-partner and partner-to-MLANA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MLANA versus HPS4 in SKIN, with a Pearson correlation of 0.56.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MLANA→partner) and Y-score (partner→MLANA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	HPS4 →	+1.188	+3.431	<.001	<.001	3	1
SKIN	RAB36 →	-1.046	-2.573	.005	.001	3	1
SKIN	SNW1 →	-0.521	-3.231	<.001	<.001	3	1
SKIN	PSMB5 →	-0.526	-2.772	.001	.001	3	1
SKIN	RASSF2 →	+1.890	+2.757	.001	.002	3	1
SKIN	TSC22D1 →	-1.348	-2.460	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 565 associations by consensus.

MLANA vs HPS4 — SKIN

Explore this scatter interactively →