MLANA

Across TCGA cell cohorts, MLANA protein abundance is significantly associated with the go_rna of many other GO terms, with 383 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible MLANA-associated GO terms across cancer lineages are Sulfur amino acid transport, Negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway, and Regulation of collagen metabolic process. Each is linked with MLANA in more than 1 cancer types. Because this analysis shows association rather than direction, both MLANA-to-partner and partner-to-MLANA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Sulfur amino acid transport grouped by MLANA-low versus MLANA-high in SKIN.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MLANA→partner) and Y-score (partner→MLANA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Sulfur amino acid transport →	+0.124	+2.779	.002	<.001	3	1
SKIN	Negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway →	+0.153	+2.841	.003	.001	3	1
SKIN	Regulation of collagen metabolic process →	-0.162	-3.325	.009	.003	3	1
SKIN	Regulation of extracellular matrix disassembly →	-0.170	-2.571	<.001	.005	3	1
SKIN	Intermembrane phospholipid transfer →	+0.064	+2.865	.002	.009	3	1
SKIN	Organelle localization by membrane tethering →	+0.044	+2.686	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 383 associations by consensus.

Sulfur amino acid transport by MLANA expression — SKIN

Explore this box plot interactively →